A University of Cincinnati (UC) cancer biology team reports breakthrough findings about specific cellular mechanisms that may help overcome endocrine (hormone) therapy-resistance in patients with estrogen-positive breast cancers, combating a widespread problem in effective medical management of the disease.
Cancer Treatment Centers of America (CTCA) and Nanospectra Biosciences have planned the first clinical trial for lung cancers of a new therapy that uses gold nanoshells, which were invented at Rice.
Scientific and medical research usually advances through the slow, painstaking accumulation of knowledge. Occasionally, however, radical ideas disrupt established patterns and may open up entirely new fields of study.
Brackets made from clear plastic polymer used in dental correction orthodontics have produced very good results in recent years, especially in relation to the improved esthetics when compared to metal brackets, but they do present certain problems of wear and tear within the mouth.
When surgeons operate to remove a tumor, determining exactly where to cut can be tricky. Ideally, the entire tumor should be removed while leaving a continuous layer of healthy tissue, but current techniques for locating the tumors during surgery are imprecise.
Researchers at Johns Hopkins have figured out the three-dimensional shape of the protein responsible for creating unique bonds within the cell wall of the bacteria that cause tuberculosis. The bonds make the bacteria resistant to currently available drug therapies, contributing to the alarming rise of these super-bacteria throughout the world.
A team of UC Davis scientists has shown in experimental mouse models that a new drug delivery system allows for administration of three times the maximum tolerated dose of a standard drug therapy for advanced bladder cancer, leading to more effective cancer control without increasing toxicity.
Mucus coats our airways' internal surfaces. The viscous gel humidifies the lungs and prevents viruses and other small particles like diesel soot from entering the body unchecked. Previously unclear was the extent to which such nanoparticles are able to move through the lungs' mucus. Here, the research evidence was contradictory.
Chesapeake PERL has received a Small Business Innovation Research award from the National Cancer Institute to continue development of a protein nanoparticle linked to an antitumor agent as a potential lung cancer therapeutic. C-PERL collaborators in the laboratory of Dr. Leonard Rome, Professor of Biological Chemistry at UCLA have identified and characterized the vault particle, a unique nanoparticle structure ubiquitous in eukaryotes.
Actinium Pharmaceuticals, Inc., (API), a private biopharmaceutical company that develops innovative targeted radio-immunotherapeutics, announced that the poster summarizing the results for Phase I study of Actimab-A, its antibody directed alpha emitter drug candidate, has won a first place poster presentation award at the 8th Annual Hematologic Malignancies 2012 Conference held in Houston, TX, from October 10-14.
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