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Microfluidic Devices to Detect Single Proteins Inside Microfabricated Polymer Arrays

Quanterix, which uses its innovative single molecule array (SiMoA) technology for developing future molecular diagnostic tests, has developed a novel technique to determine single proteins inside the microfabricated polymer arrays fabricated by Sony DADC.

Recently, Quanterix signed a partnership deal with Sony DADC to develop and produce smart consumables using an optical disc format. Quanterix’s Vice President of Research, David Duffy stated that the company has created a tool to fluidically isolate and seal individual molecules in polymer arrays comprising numerous microscopic wells. These consumables are produced utilizing highly accurate mass production processes and will be the basis of the SiMoA tool that is being developed by the company, Duffy said. The company can carry out SiMoA in a completely automated manner by utilizing arrays that are confined in microfluidic channels, he added.

Duffy further said it is a major breakthrough en route to achieve the company’s objective of creating an automated platform that allows single molecule detection, while providing meaningful benefits for the production of economical, superior-quality consumables. These devices will assist sensitive detection and high output of biomarkers, and deal with critical applications in in-vitro diagnostics and life science research.

The Chairman and Chief Executive Officer at Quanterix, Martin Madaus stated that this is a major landmark towards the commercialization of the SiMoA technology. The company, together with its strategic partners, intends to design and produce a completely automated tool for its SiMoA technology that will use these devices in a range of diagnostic tests. The company plans to introduce the life science tool in the fiscal year 2013, followed by the commercialization of an IVD platform in the fiscal year 2014.

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