THALIA is an InProcess solution for protein and nanoparticle analysis designed specifically for low-concentration applications.
The NanoFlowSizer
- Powerful PAT tool
- Measure non-invasive in any transparent container
- High sensitivity in low concentrations
- Unique Spatially Resolved DLS technology
- Proprietary technology
Your Solution For
- Aggregation monitoring
- In-line Design of Experiments: Formulation screening
- Large particle detection (imaging)
- Protein analysis for ADC, mAb, pAb, viruses
- Stability screening
Features and Benefits
- Cost-effective real-time monitoring reduces operational costs
- Reduced risk of batch failures
- Real-time, continuous data collection (< 5 seconds)
- (Very small) particle size and size distribution
- Measurement in low-concentrated materials
- XsperGo software is GMP compliant - OPC-UA compatible
- Fully customizable to specific processes; modules available for lab, pilot, and manufacturing scale
Image Credit: InProcess-LSP
The THALIA system offers us a powerful tool for protein analysis, such as monoclonal antibodies (mAbs). It also allows precise monitoring of aggregation formation in our process.
Image Credit: InProcess-LSP
Thalia
Perfect for analysis in low concentrations and in the low nanometer range.
Image Credit: InProcess-LSP
Software Solutions:
- Large Particle Detection (LPD): Live imaging of particle aggregation
- PhaSR: An increase in the analysis range's sensitivity
- Compliant with GMP and compatible with OPC-UA
Hardware Solutions:
- Trolley-mounted systems
- Customized system configuration for small, medium, large scale flow- and offline analysis
System Features
Source: InProcess-LSP
| |
THALIA |
| Measurement principle |
Spatially Resolved Dynamic Light Scattering (SR-DLS) |
| Particle Size Range |
3 nm - 5000 nm |
| Measurement angle |
180° backscatter |
| Measuring mode |
Flow & static |
| Configuration |
Inline, online, at-line, offline |
| Data collection |
Real-time / Continuous < 5 seconds/datapoint |
| Flow Rate |
< 250 L/hour |
| Wavelength |
1250 to 1350 nm |
| Turbidity* |
Very low to high |
| Sample size |
> 1 mL |
* Turbidity ranges are particle type and solvent dependent and need to be experimentally determined