FIDES: Advanced Nanoparticle Sizing for Turbid Sample Analysis in Real-Time

InProcess' FIDES is the ideal instrument for accurately characterizing nanoparticle size in turbid sample analysis.

The NanoFlowSizer

• Enables non-invasive measurements in any transparent container
• Proprietary technology
• A powerful tool for PAT
• Unique Spatially Resolved DLS Technology
• Facilitates real-time analysis of highly turbid samples

Solution for

• LNP Manufacturing
• Large Particle Detection (Imaging) In-line Design of Experiments: Formulation Screening
• Active Pharmaceutical Ingredient Milling
• Emulsification and HPH) Process Monitoring
• Crystallization and Polymerization
• Aggregation Monitoring 

Features and Benefits

• Continuous data collection in real time (< 5 seconds)
• XsperGo software is compliant with Good Manufacturing Practices (GMP) and compatible with OPC-UA
• Measurement of particle size and size distribution
• Decreased risk of batch failures
• Fully customizable to meet specific process requirements; modules available for laboratory, pilot, and manufacturing scales
• Cost-effective real-time monitoring that reduces operational costs

Image Credit: InProcess-LSP 

Integrating the NanoFlowSizer FIDES has significantly reduced batch failures in our vaccine production through precise inline monitoring.

Image Credit: InProcess-LSP 

FIDES

Perfect for analyzing lipid nanoparticles and both organic and inorganic nanoparticles.

Image Credit: InProcess-LSP 

Hardware Solutions:

• Online Micro Dilution (OMD): The solution for extremely high turbidities and concentrations
• Customized system configuration for small, medium, and large-scale flow and offline analysis
• Trolley-mounted systems

Software Solutions:

• Large Particle Detection (LPD): Additional imaging feature
• PhaSR: The solution for very low particle sizes and low concentrations

System Features

Source: InProcess-LSP

* Turbidity ranges are particle type and solvent dependent and need to be experimentally determined