Litesizer DLS provides best-in-class particle sizing with automatic angle selection to avoid errors, while MAPS technology achieves the greatest possible peak resolution. Continuous transmittance monitoring detects sedimentation and agglomeration during measurement, which improves measurement reliability.
101
Image Credit: Anton Paar GmbH
- Particle sizes range from 0.3 nm to 10 µm
- An affordable entry to dynamic light scattering
- Broad sample coverage is ensured using DLS back-scatter detection
- Measurement of transmittance to continuously observe sample behavior
501
Image Credit: Anton Paar GmbH
- Size range of particles: 0.3 nm to 12 µm
- Advanced dynamic scattering of light at three angles of measurement
- Zeta potential determination with patented cmPALS
- Measurements of molecular mass and refractive index
- Polarization and fluorescent filters for every angle
701
Image Credit: Anton Paar GmbH
- Size range of particles: 0.3 nm to 12 µm
- An advanced dynamic light scattering device with all modes
- Polarization and fluorescence filters for every angle
- Multi-angle particle sizing (MAPS) for high resolution
- Determination of concentration for up to three size classes
Exclusive to the system, by addressing the effects of aging and reducing the electrical gradient, cmPALS and Omega Cuvette increase zeta potential accuracy and repeatability.
Litesizer DLS also provides fluorescence and polarization filters for particle concentration measurements in single-angle and three-angle MAPS modes, as well as particle size measurements.
Key Features
Three Angles, Real-Time Monitoring for Better Sizing
Image Credit: Anton Paar GmbH
With its automatic angle selection, Litesizer DLS eliminates errors while providing a choice of three detection angles for measuring a broad range of samples.
The remarkable resolution provided by the Multi-Angle Particle Sizing (MAPS) measurement mode supports advanced analytical precision.
Continuous transmission monitoring, exclusive to the market, gives consumers real-time input on sample behavior throughout the measurement, providing them with immediate knowledge of sedimentation or agglomeration. Because of this real-time information, the system is the best option for precise and trustworthy particle analysis, improving measurement quality and reliability.
Market-Leading Zeta Potential Analysis
Image Credit: Anton Paar GmbH
The patented cmPALS technique of Anton Paar's dynamic light scattering instrument is specifically engineered to remove reproducibility uncertainties resulting from aging effects.
The patented cmPALS method of the dynamic light scattering instrument is specifically made to remove repeatability uncertainties caused by aging effects.
The inventive design of the Omega Cuvette reduces the electrical field gradient, which improves reproducibility by an additional ± 3%. With a zeta potential measuring particle size range of 1.3 nm to 100 µm, which leads the market, our instrument has the widest capability available, guaranteeing accurate and reliable findings for various applications.
Kalliope: The Benchmark Software for Particle Sizing
Image Credit: Anton Paar GmbH
Very minimal user training is necessary for the Kalliope software.
Just three clicks are needed to complete measurements. Everything the user needs is at the fingertips, thanks to the special one-page layout, which instantly summarizes input parameters, measurement signals, and findings. Measurement findings can be accessed quickly using structured result summaries and predefined standard reports.
Use the customizable report templates, Excel export options, and advanced analysis functions for more detailed analysis. Kalliope is also fully compliant with 21 CFR Part 11, ensuring robust data integrity and regulatory adherence.
All the Measuring Modes Needed
Image Credit: Anton Paar GmbH
The particle concentration measurement mode of the Litesizer DLS 701 increases versatility by allowing concentration analysis for up to three different-size populations in a single sample without the need for calibration. Whether they are using single-angle DLS or MAPS, this mode can handle both monodisperse and polydisperse samples over a broad concentration range.
To ensure the highest precision for particle size and zeta potential data, measure the refractive index of solvents at the precise wavelength and temperature of your measurements (European Patent 3 023 770). Refractive index readings from the Litesizer DLS 701 and DLS 501 are accurate to within ±0.5%.
Moreover, molecular mass measurement is another feature of the Litesizer DLS series.
Most Capable Filtering Options Available
Image Credit: Anton Paar GmbH
The only dynamic light scattering devices that allow users to apply polarization or fluorescence filters in all three angle directions are the Litesizer DLS 701 and 501. This makes particle concentration analysis, MAPS three-angle analysis, and chosen single-angle analysis with applied filters possible, allowing for types of analysis that are not achievable with similar devices (e.g., concentration resolution of quantum dots).
Technical Specifications
Source: Anton Paar GmbH
| |
Litesizer
DLS 701 |
Litesizer
DLS 501 |
Litesizer
DLS 101 |
| Particle size specifications |
| Measurement principle |
Dynamic Light Scattering (DLS) |
| Measuring range |
0.3 nm to 12 μm* (particle diameter) |
0.3 nm to 10 μm* (particle diameter) |
| Measurement angles |
15°, 90°, 175°, Multi-angle particle sizing (MAPS) |
15°, 90°, 175° |
175° |
| Min. concentration |
0.1 mg/mL (lysozyme)
lower than 0.00001 % (0.1 ppm, Latex 100 nm) |
0.1 mg/mL (lysozyme) |
| Max. concentration |
50 % w/v (sample-dependent) |
| Min. sample volume |
1.5 µL |
12 µL |
| Accuracy |
Better than +/-2 % on NIST traceable standards |
| Repeatability |
Better than +/-2 % on NIST traceable standards |
| Particle Concentration Specifications |
| Analysis model |
Mie Theory |
- |
- |
| Measuring range |
108 - 1013 particles/mL (sample dependent) |
- |
- |
| Size limit |
1 µm |
- |
- |
| Measurement angles |
15°, 90°, 175°, Multi-angle particle sizing (MAPS) |
- |
- |
| Min. sample volume |
12 µL |
- |
- |
| Accuracy |
+/- 10 % (sample dependent) |
- |
- |
| Repeatability |
+/- 5 % (sample dependent) |
- |
- |
| Zeta potential specifications |
| Measuring principle |
Electrophoretic Light Scattering (ELS) / cmPALS |
- |
| Measuring range |
>= +/-1000 mV |
- |
| Mobility range |
10-11 m²/V.s to 2 x 10-7 m²/V.s |
- |
| Size range |
1.3 nm to 100 µm (diameter) |
- |
| Min. sample concentration |
0.1 mg/mL (lysozyme) |
- |
| Max. sample concentration |
70 %w/v (sample-dependent) |
- |
| Max. sample conductivity |
200 mS/cm |
- |
| Min. sample volume |
50 µL (sample-viscosity-dependent) |
- |
| Accuracy |
Better than +/-10 % |
- |
| Repeatability |
+/-3 % |
- |
| Molecular mass specifications |
| Measuring principle |
Static Light Scattering (SLS) |
- |
| Measuring range (mass) |
300 Da to 20 MDa |
- |
| Measuring range (particle size) |
Up to 40 nm (diameter) |
- |
| Measurement angle |
90° |
- |
| Min. sample concentration |
0.1 mg/mL (lysozyme) |
- |
| Accuracy |
+/-10 % |
- |
| Repeatability |
+/-5 % |
- |
| Transmittance specifications |
| Measuring range |
0 % to 100 % |
| Min. sample volume |
1.5 µL |
| Accuracy |
Better than +/-1 % |
| Refractive index specifications |
| Measuring range |
1.28 to 1.50 |
- |
| Min. sample volume |
1 mL |
- |
| Accuracy |
+/-0.5 % |
- |
| General specifications |
| Light source |
Semiconductor laser diode / 40 mW, 658 nm |
| Optical filters (fluorescence, vertical and horizontal polarization) |
forward, side and backscattering |
- |
| Laser warm-up time |
6 min |
| Temperature control range |
0 °C to 120 °C |
| Ambient operating temperature |
10 °C to 35 °C |
| Humidity |
Up to 80 % non-condensing |
| Dimensions (W, D, H) |
450 mm, 505 mm, 135 mm |
| Weight |
Approx. 18 kg
(40 lb) |
Approx. 16.3 kg
(36 lb) |